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为了观察区域性动脉灌注化疗治疗晚期胰腺癌的作用。方法 采用Seldinger法 ,选择性置导管于胰腺癌的供血动脉内 ,尽可能将导管接近肿瘤后注入化疗药物 ,以提高胰腺癌组织局部的药物浓度 ,更充分地杀伤癌细胞 ,提高疗效。结果 对 33例晚期胰腺癌动脉灌注化疗 ,病灶缩小 2 5 %以上者 2 6例 ,有效率占 79% ;2 7例疼痛症状不同程度的缓解与消失 ;13例黄疸治疗后减轻者 5例 ,消退者 8例 ;33例均未出现肝肾功能严重损害。结论 晚期胰腺癌通过动脉灌注化疗能获得较高的生存质量。
In order to observe the role of regional arterial infusion chemotherapy in the treatment of advanced pancreatic cancer. Methods The Seldinger method was used to selectively place the catheter in the feeding artery of pancreatic cancer. The catheter was injected with chemotherapeutic drugs as close to the tumor as possible to increase the local drug concentration in the pancreatic cancer tissue and kill the cancer cells more fully to improve the curative effect. Results Twenty-three patients with advanced pancreatic cancer were treated with arterial infusion chemotherapy, 26 cases with lesions reduced by 25% or more, the effective rate was 79%, 27 cases were relieved or disappeared with varying degrees of pain symptoms, 13 cases were relieved after jaundice treatment, 8 cases of dissipated; 33 cases did not appear serious damage to liver and kidney function. Conclusion Advanced pancreatic cancer can obtain higher quality of life through arterial infusion chemotherapy.