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目的:探讨纳洛酮联合门冬氨酸鸟氨酸治疗肝硬化导致肝性脑病临床治疗效果及应用价值。方法:选择我院治疗的肝硬化导致肝性脑病患者76例作为研究对象,采取随机数字表法分为观察组和对照组,每组各38例,对照组采用西医常规治疗,观察组在对照组治疗基础上联合纳洛酮和门冬氨酸鸟氨酸治疗,观察疗效。结果:观察组治疗总有效率高于对照组,经统计学分析比较,差异具有统计学意义(P<0.05)。观察组患者治疗后血氨浓度、格拉斯哥昏迷量表评分改善均好于对照组,经统计学分析比较,差异具有统计学意义(P<0.05)。结论:纳洛酮联合门冬氨酸鸟氨酸治疗肝硬化导致肝性脑病疗效可靠,降低患者血氨浓度,有效改善患者意识障碍程度,值得在临床上大力推广使用。
Objective: To investigate the clinical effect and application of naloxone combined with aspartate ornithine in the treatment of hepatic cirrhosis caused by cirrhosis. Methods: Seventy-six patients with hepatic encephalopathy who were treated by our hospital were enrolled in this study. The random number table was divided into observation group and control group, with 38 cases in each group. The control group was treated with western medicine routinely. Based on the combination of naloxone and aspartate ornithine treatment, the curative effect was observed. Results: The total effective rate of observation group was higher than that of control group, and the difference was statistically significant (P <0.05). After treatment, the blood ammonia concentration and the Glasgow coma scale in the observation group were better than those in the control group, and the difference was statistically significant (P <0.05). CONCLUSION: Naloxone combined with aspartate ornithine in the treatment of liver cirrhosis leads to reliable therapeutic effect on hepatic encephalopathy. It can reduce the concentration of ammonia in patients and improve the degree of disturbance of consciousness in patients. Therefore, it is worth to be widely used clinically.