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将52例百草枯(PQ)中毒患者根据临床转归分为死亡组A(17例,1周内死亡)、死亡组B(10例,1周后死亡)和存活组(25例),另选20例作对照组,检测血清肿瘤坏死因子(TNF-α)、白细胞介素-6(IL-6)、白细胞介素-1β(IL-1β)水平,并行血气分析。结果死亡组A动脉血气分析各指标低于对照组及存活组,死亡组B碱剩余(BE)、碳酸氢盐(HCO-3)低于存活组;死亡组血清TNF-α、IL-6、IL-1β水平高于存活组,并与动脉血氧分析呈负相关(P<0.05)。提示TNF-α、IL-6、IL-1β参与了PQ中毒的发病过程,与患者的预后存在相关性,可作为判断患者病情严重程度及转归的预测指标。
Fifty-two patients with paraquat (PQ) poisoning were divided into two groups: death group A (17 patients died within 1 week), death group B (10 patients died after 1 week) and survival group (25 patients) Twenty patients were selected as the control group. Serum levels of tumor necrosis factor (TNF-α), interleukin-6 (IL-6) and interleukin-1β (IL- Results The indexes of arterial blood gas analysis in death group A were lower than those in control group and survival group. The levels of B, B and HCO-3 in death group were lower than those in survival group. The levels of TNF-α, IL-6, The level of IL-1β was higher than that of survival group, and was negatively correlated with arterial oxygenation (P <0.05). These results suggest that TNF-α, IL-6 and IL-1β are involved in the pathogenesis of PQ poisoning and are correlated with the prognosis of patients. They may be used as predictors of the severity and outcome of patients.