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目的探讨斑状角膜营养不良患者的临床特征、诊断及手术治疗。设计回顾性病例系列。研究对象18例(36眼)斑状角膜营养不良患者。方法分析患者临床资料,包括病史、视力、裂隙灯显微镜检查以及手术治疗方法和术后随访结果。主要指标角膜病变及角膜移植片的裂隙灯显微镜图像。结果斑状角膜营养不良患者的临床表现有双眼视力进行性下降;裂隙灯显微镜检查发现双眼角膜基质雾状混浊,间以局灶性斑块或结节状灰白色混浊,斑块状混浊在中央部位于基质浅层而在周边则位于深层。在所有患者中行穿透性角膜移植术者14例(18眼),随访6至112个月,角膜植片均保持清亮。结论斑状角膜营养不良有其特征性临床表现,据此可明确诊断。对于中重度患者,穿透性角膜移植术是一种有效的治疗手段。(眼科,2006,15:169-172)
Objective To investigate the clinical features, diagnosis and surgical treatment of patients with patchy corneal dystrophy. Design retrospective case series. Study object 18 cases (36 eyes) macular dystrophy patients. Methods Clinical data of patients were analyzed, including history, visual acuity, slit lamp microscopy and surgical treatment and postoperative follow-up results. The main indicators of corneal lesions and corneal graft slit lamp microscope images. Results The clinical manifestations of macular dystrophy patients with binocular vision decreased; Slit lamp microscopy found corneal opacity of both corneal matrix, between focal plaque or nodular gray turbidity, plaque-like cloudy in the central part of the The superficial layer of the matrix is located deep in the periphery. In all patients, penetrating keratoplasty was performed in 14 patients (18 eyes). The follow-up ranged from 6 to 112 months. The corneal grafts remained clear. Conclusions Corneal dyskeratosis has its characteristic clinical manifestations, which can confirm the diagnosis. Penetrating keratoplasty is an effective treatment for moderate-severe patients. (Ophthalmology, 2006,15: 169-172)