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梭曼,GABA和谷氨酸在离体蚯蚓(Eisenia foetida)背肌上的效应经40℃、10％(NH_4)_2SO_4或1％Triton X-100膜处理后都可被消除,但AGh反应仍存在,蚯蚓背肌GhE活性要比处理前高得多。在未经膜处理,但ACh效应、GABA效应或谷氨酸效应被阻断的标本上,梭曼仍引起肌缩反应。所以,我们认为梭曼的肌缩效应不是作用在ChE或ACh受体、GABA受体及谷氨酸受体上,而是与另一膜蛋白质相互作用的结果, 并提出蚯蚓背肌可能存在“梭曼受体”的假说。
The effects of soman, GABA and glutamic acid on the muscle of Eisenia foetida were eliminated after treatment with 40%, 10% (NH 4) 2 SO 4 or 1% Triton X-100, but the AGh reaction was still Exist, earthworm back muscle GhE activity was much higher than before treatment. In the non-membrane treatment, but ACh effect, GABA effect or glutamate effect was blocked specimens, soman still cause muscle contraction. Therefore, we think that the somatosensory effect of soman does not act on ChE or ACh receptors, GABA receptors and glutamate receptors but rather as a result of the interaction with another membrane protein and suggests that there may be “ Soman receptor ”hypothesis.