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目的:对氢醌-β-环糊精包和物(HD-β-CD)的处方及制备工艺进行优化。方法:采取饱和水溶液法制备HD-β-CD,用正交试验设计,分别以包合率和成品率为指标,筛选HD-β-CD的最佳处方及制备工艺,并采用形态观察、化学试剂法及差示扫描分析对其进行了验证。结果:HD-β-CD的最佳处方及工艺为:HD与β-CD质量比为1:2,包和温度为30℃,搅拌时间为6.5h,搅拌速度为180r·min~(-1)。验证试验结果均证实HD-β-CD的形成。结论:优选的HD-β-CD的包合率及成品率均较好,该处方及制备工艺较优,HD-β-CD成功包合。
OBJECTIVE: To optimize the formulation and preparation of hydroquinone-β-cyclodextrin inclusion complex (HD-β-CD). Methods: HD-β-CD was prepared by saturated aqueous solution. The optimum formulation and preparation process of HD-β-CD were screened by orthogonal design. The inclusion rate and yield were used as indexes. Reagent method and differential scanning analysis to verify it. Results: The optimal formulation and process of HD-β-CD were as follows: the mass ratio of HD to β-CD was 1: 2, the temperature and package temperature were 30 ℃, the stirring time was 6.5h, the stirring speed was 180r · min -1 ). Verification test results confirm the formation of HD-β-CD. Conclusion: The inclusion rate and yield of the preferred HD-β-CD are good, the prescription and preparation process is better, HD-β-CD was successfully included.