以2-苄硫基-5-甲基-7-羟基-1,2,4-三唑并[1,5-a]嘧啶为起始原料,经过醚化、氧化反应分别合成了12个新型的2-苄硫基-5-甲基-7-取代苄氧基-1,2,4-三唑并[1,5-a]嘧啶类化合物5a～5l及其砜基类似物6a～6l,并通过1H NMR,IR,MS和元素分析对所有目标化合物进行了结构表征.初步生物活性测试结果表明,在50μg/mL浓度下,部分化合物表现出了一定的抑菌活性,其中化合物5c,5k和5l对黄瓜灰霉病菌的抑制率分别为61%,69%和85%. Starting from 2-benzylthio-5-methyl-7-hydroxy-1,2,4-triazolo [1,5-a] pyrimidine, twelve novel 2-benzylthio-5-methyl-7-substituted benzyloxy-1,2,4-triazolo [1,5-a] pyrimidines 5a to 5l and their sulfone analogs 6a to 6l , And all the target compounds were characterized by 1H NMR, IR, MS and elemental analysis.The preliminary bioassay results showed that some compounds showed certain antibacterial activities at the concentration of 50μg / mL, of which compounds 5c, The inhibitory rates of 5k and 5l to Botrytis cinerea were 61%, 69% and 85% respectively.