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目的:探讨原发性高血压患者动态动脉硬化指数(AASI)与血浆致动脉硬化指数(AIP)之间的关系。方法:利用常规的24小时动态血压监测数据测定及计算96例原发性高血压患者动态动脉硬化指数,并用彩色多普勒血流显像仪测定颈动脉内膜中层厚度以及全自动生化分析仪测定及计算血浆致动脉硬化指数,进行统计学处理及相关分析。结果:在AASI高水平组单因素直线相关分析显示,IMT除与HDL-C呈负相关(r=-0.190)外,与TG、TC、LDL-C及AIP均呈正相关,与AIP相关系数最高(r=0.492p<0.01)。结论:AIP与AASI、IMT一样可以作为测定血管早期改变及临床血管病变的方法,判断心血管事件的发生及预后,为早期和方便的检出心血管高危患者提供客观指标,为高血压及动脉硬化的临床防治;为临床对高血压的风险因素早期采取措施进行干预提供了依据,AASI、AIP作为高血压及动脉硬化指标,具有临床实用价值。
Objective: To investigate the relationship between dynamic arteriosclerosis index (AASI) and plasma atherosclerosis index (AIP) in patients with essential hypertension. Methods: The dynamic arteriosclerosis index of 96 patients with essential hypertension was measured and measured by routine 24-hour ambulatory blood pressure monitoring data. The carotid intima-media thickness was measured by color Doppler flow imaging and the automatic biochemical analyzer Determination and calculation of plasma atherosclerosis index, statistical analysis and correlation analysis. Results: In the high-level AASI single-factor linear correlation analysis, IMT was positively correlated with TG, TC, LDL-C and AIP except the negative correlation with HDL-C (r = -0.190) (r = 0.492p <0.01). Conclusions: AIP, like AASI and IMT, can be used as a method to determine the early changes of vascular and clinical vascular pathology, to determine the occurrence and prognosis of cardiovascular events and provide objective indicators for early and convenient detection of cardiovascular high risk patients. Sclerotic clinical prevention and treatment for clinical risk factors for hypertension to take early intervention to provide the basis for AAS, AIP as indicators of hypertension and atherosclerosis, with clinical practical value.