近年来 ,随着医学分子生物学的发展 ,肝纤维化发病机制研究有了较大进步。目前认为肝纤维化发生不仅是由于肝内的细胞外基质 (ｅｘｔｒａｃｅｌｌｕｌａｒｍａ ｔｒｉｘ ,ＥＣＭ )合成过多 ,而且与ＥＣＭ降解水平有着密切关系。在肝内参与ＥＣＭ降解的主要是一组名为基质金属蛋 In recent years, with the development of medical molecular biology, the study of pathogenesis of liver fibrosis has made great progress. It is currently believed that hepatic fibrosis occurs not only because of excess synthesis of extracellular matrix (ECM) in the liver, but also by the level of ECM degradation. A major group of molecules that are involved in the degradation of ECM in the liver are called matrix metal eggs