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目的探讨新疆地区垂体瘤患者血管内皮生长因子(Vascular endothelial growth factor,VEGF)的表达及其意义。方法选择我院所收治的52例垂体瘤患者,其中未复发者29例,复发者23例,应用免疫组化法对其脑垂体瘤中VEGF表达进行检测。结果 52例中,有42例出现VEGF表达阳性,复发组垂体瘤中VEGF表达较未复发组明显增高,两组间差异有统计学意义(P<0.05)。结论 VEGF在垂体瘤血管形成中发挥重要作用,可能促进垂体瘤的复发。
Objective To investigate the expression of vascular endothelial growth factor (VEGF) in patients with pituitary adenoma in Xinjiang and its significance. Methods 52 cases of pituitary adenomas treated in our hospital were selected, including 29 cases without recurrence and 23 cases with recurrence. The expression of VEGF in pituitary adenoma was detected by immunohistochemistry. Results Of the 52 cases, VEGF expression was positive in 42 of the 52 cases. The expression of VEGF in the recurrence group was significantly higher than that in the non-recurrence group. There was significant difference between the two groups (P <0.05). Conclusion VEGF plays an important role in the angiogenesis of pituitary tumors and may promote the recurrence of pituitary tumors.