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目的:观察利奈唑胺治疗老年髓系白血病患者合并革兰阳性球菌感染的临床疗效。方法:选取2013年1月-2015年5月我院收治的老年髓系白血病患者合并革兰阳性球菌感染患者80例,随机分成观察组和对照组,每组40例,观察组采用利奈唑胺治疗,对照组采用常规的头孢哌酮抗感染治疗,观察两组治疗效果。结果:经治疗后,观察组患者的治疗总有效率明显高于对照组,组间比较,差异具有统计学意义(P<0.05)。两组患者均未出现严重的过敏反应、心功能异常、肝功能异常以及肾功能异常症状。结论:对老年髓系白血病患者合并革兰阳性球菌感染患者在抗感染治疗的基础上实施利奈唑胺治疗,能够显著提高患者的疗效。
Objective: To observe the clinical efficacy of linezolid in the treatment of elderly patients with myeloid leukemia combined with gram-positive cocci infection. Methods: From January 2013 to May 2015, 80 elderly patients with acute myeloid leukemia who were admitted to our hospital were randomly divided into observation group and control group, 40 cases in each group. The observation group was treated with linezolid The patients in the control group were treated with cefoperazone anti-infection routinely. The therapeutic effect was observed in both groups. Results: After treatment, the total effective rate of observation group was significantly higher than that of control group. There was significant difference between two groups (P <0.05). No severe allergic reaction, abnormal cardiac function, abnormal liver function and abnormal renal function occurred in both groups. Conclusion: Linezolid treatment based on anti-infective therapy in elderly patients with myeloid leukemia combined with gram-positive cocci infection can significantly improve the efficacy of the treatment.