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目的 为了研究哮喘发作致死患者肺组织嗜酸性粒细胞浸润情况。方法 研究分成 3组 ,A组为死于哮喘发作 ,B组有哮喘病史但死于非哮喘发作 ,C组无哮喘病史。应用免疫组化技术 ,检测不同死因肺组织单克隆抗体EG1 和EG2 的阳性细胞。结果 ( 1)哮喘发作致死组的肺组织EG1 和EG2 的阳性细胞明显高于其他两组 ,而哮喘患者非哮喘发作致死组的肺组织EG1 和EG2 的阳性细胞与无哮喘病史组比较无显著差异。 ( 2 )在哮喘发作致死组的支气管与肺实质EG1 阳性细胞数无明显差异 ,但在肺实质的EG2 的阳性细胞明显高于较大的支气管。结论 在哮喘发作致死患者气道和肺组织有大量的嗜酸性粒细胞浸润 ,且以小支气管与肺实质浸润为主
Objective To study the lung tissue eosinophil infiltration caused by asthma attacks. Methods The study was divided into 3 groups, group A died of asthma attack, group B had asthma history but died of non-asthma attack, group C had no history of asthma. Immunohistochemistry was used to detect the positive cells of monoclonal antibodies EG1 and EG2 in lung tissue of different causes of death. Results (1) The positive cells of EG1 and EG2 in the lung tissue of the lethal group were significantly higher than those in the other two groups. There was no significant difference in the positive cells of EG1 and EG2 in the lung tissue of the non-asthmatic group . (2) There was no significant difference in the number of EG1 positive cells in the bronchi and lung in the blast-induced death group, but the positive cells in the lung parenchyma EG2 were significantly higher than those in the larger bronchi. Conclusion A large number of eosinophil infiltration in the airways and lungs of patients who died of asthma attacks were mainly found in small bronchial and pulmonary infiltrates