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目的了解西部地区健康女性宫颈高危型HPV的感染情况、年龄分布特点及其与宫颈细胞学之间的关系。方法前瞻性分析2010~2011年到华西医院体检女性的宫颈高危型HPV检测及细胞学结果。结果本研究共纳入研究对象3 443名,总体阳性率为21.49%。其中,60(含)~65岁年龄段阳性率最高,阳性率为28.57%,除阳性率最低的70岁(含)以上年龄段外,30岁以下的年龄段最低(P﹤0.05)。在702名高危型HPV感染者中,细胞学异常者为2.14%,与HPV感染阴性者比较,两者间差异有统计学意义(P﹤0.05)。结论正常人群中,60(含)~65岁年龄段的女性是HPV感染的高峰人群,宫颈高危型HPV的感染较前有年轻化的趋势,感染率有增高的趋势,感染后并不一定会出现宫颈上皮内瘤变。HPV检测在协助分析不正常的细胞学结果中,具有重要的临床意义。
Objective To understand the infection, age distribution and the relationship with cervical cytology in high risk HPV genotypes of healthy women in western China. Methods Prospective analysis of 2010-2011 to the West China Hospital physical examination of women with high-risk cervical HPV testing and cytology results. Results A total of 3 443 subjects were enrolled in this study, with an overall positive rate of 21.49%. Among them, 60 (inclusive) to 65 years of age the highest positive rate, the positive rate was 28.57%, except for the lowest positive rate of 70 years of age (inclusive) above the age group below 30 years of age the lowest (P <0.05). Among 702 patients with high-risk HPV infection, the abnormality of cytology was 2.14%, which was significantly different from that of HPV-negative patients (P <0.05). Conclusion In the normal population, women aged 60 (inclusive) ~ 65 years are the peak of HPV infection. The infection of high-risk HPV is younger and the infection rate tends to be higher. It may not be the case after infection Cervical intraepithelial neoplasia appears. HPV testing has important clinical implications in assisting with the analysis of abnormal cytologic findings.