论文部分内容阅读
３－甲基胆蒽（ＭＣＡ）碘油溶液诱发大鼠肺癌过程中，用黄芪注射液及扶正流浸膏分别进行抑癌实验。发癌率（％）：黄芪组１６．２８，扶正组３６．９６，对照组５１．５２。黄芪组发癌率与对照组比较差异有非常显著性（Ｐ＜０．００５）。扶正组发癌率与对照组比较差异无显著性（０．２５＞Ｐ＞０．１）。光镜和透射电镜观察，各组癌例均为肺鳞癌，黄芪组与对照组不同，其特点：癌巢规整，核分裂相极少，核空化，明显角化，癌细胞表面突起锐减或肿胀，线粒体与粗面内织网极度扩张，膜结构破坏，枚染色质凝集、固结、核空化等，最后癌细胞崩解及消失。结果表明：黄芪注射液有明显抑癌效果。扶正组肺癌组织形态学呈退行性交的特点与黄芪组相似，据此，扶正流浸膏也可能有抑癌作用。
In the process of lung cancer induced by 3-methylcholanthrene (MCA) iodized oil solution, tumor suppressor experiments were performed with Huangqi injection and Fuzhengliu extract. The incidence of cancer (%): Astragalus group 16.28, Fuzheng group 36.96, control group 51.52. There was a significant difference in the cancer rate between the Astragalus group and the control group (P < 0.005). There was no significant difference in the cancer development rate between the Fuzheng group and the control group (0.25>P>0.1). Observed by light microscope and transmission electron microscope, each group of cancer cases were squamous cell carcinoma of the lung, and the Astragalus group was different from the control group. Its characteristics were: regular nests, few mitoses, nuclear cavitation, apparent keratinization, and sharp reduction of the surface of cancer cells. Or swelling, mitochondria and rough mesh in the extreme expansion of the network, membrane structure destruction, chromatin condensation, consolidation, nuclear cavitation, and finally the cancer cells disintegrate and disappear. The results showed that: Astragalus Injection has a significant anti-cancer effect. The morphological features of lung cancer in the Fuzheng group are similar to those of the Huangqi group. Therefore, the Fuzhengliu extract may also have anticancer effects.