论文部分内容阅读
目的 了解NO在先天性心脏病中的作用及临床意义。方法 用Geriss硝酸盐还原法测定几种先天性心脏病患儿和正常对照组的NO水平。结果 与对照组相比 ,室间隔缺损 (VSD)患儿、房间隔缺损 (ASD)患儿、动脉导管未闭 (PDA)患儿NO水平增高且有显著差异 (P <0 0 5 ) ;法洛氏四联症 (F4)患儿NO水平降低但无显著差异 (P >0 0 5 )。其中先天性心脏病伴肺动脉高压者NO水平高于对照组且有显著差异 (P <0 0 5 ) ;而先天性心脏病无肺动脉高压者与对照组相比无显著差异 (P >0 0 5 )。结论 NO在先天性心脏病中起一定的作用 ,特别在先天性心脏病伴肺动脉高压中起重要作用
Objective To understand the role of NO in congenital heart disease and its clinical significance. Methods The NO level in children with congenital heart disease and normal control group was determined by Geriss nitrate reduction method. Results Compared with the control group, the levels of NO in children with VSD, children with ASD and PDA were significantly increased (P <0.05) NO levels in children with Rockwell’s disease (F4) decreased but no significant difference (P> 0.05). The level of NO in congenital heart disease with pulmonary hypertension was significantly higher than that in control group (P <0.05), while there was no significant difference in patients with congenital heart disease without pulmonary hypertension (P> 0.05). ). Conclusion NO plays a role in congenital heart disease, especially in congenital heart disease with pulmonary hypertension