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过敏性紫癜(HSP)的患儿约20%～50%并发肾炎,大多数患儿在起病后数周或数月出现肾脏损害表现,HSP的远期预后取决于肾脏损害的严重性。因此,肾炎的预防对HSP的远期预后非常重要,已有的资料提示皮质类固醇治疗对已发生的紫癜性肾炎的病程和结果没有明显的影响,该研究目的是探讨早期的皮质类固醇治疗能否预防HSP肾炎。病人和方法1979年～1991年在费吉尼亚大学健康科学中心的全部急性HSP患儿为观察对象。肾炎确诊指有肉眼或镜下血尿(离心标本RBC>5/HP),伴或不伴蛋白尿。观察了全部患儿的急性期,从起病
Allergic purpura (HSP) in children with about 20% to 50% of nephritis, most children with kidney damage after weeks or months onset, long-term prognosis of HSP depends on the severity of renal damage. Therefore, the prevention of nephritis is very important for the long-term prognosis of HSP. The existing data suggest that corticosteroid therapy has no obvious effect on the course and outcome of purpura nephritis that has occurred. The purpose of this study is to explore whether early corticosteroid therapy can Prevent HSP nephritis. PATIENTS AND METHODS All patients with acute HSP from the University of Virginia Health Science Center from 1979 to 1991 were observed. Nephritis is diagnosed with gross or microscopic hematuria (centrifuge specimen RBC> 5 / HP), with or without proteinuria. All children were observed in the acute phase, from the onset