目的探讨以反复肢体瘫痪为首发症状的甲亢的临床特点,提高对甲亢性周期性瘫痪的认识。方法分析12例以反复肢体瘫痪为首发症状甲亢患者的临床资料。结果 12例患者均有四肢或下肢瘫痪伴低钾血症,T3、T4均高于正常,TSH均低于正常,经甲亢治疗后肢体瘫痪未再发作。结论临床上遇到四肢对称性软瘫的男性患者,应想到甲亢的可能并常规做甲状腺功能检查。 Objective To investigate the clinical features of hyperthyroidism with repeated limb paralysis as the first symptom and to improve the cognition of periodic paralysis of hyperthyroidism. Methods Clinical data of 12 patients with hyperthyroidism who suffered from paralysis of their limbs were analyzed. Results All the 12 patients had limbs or lower limb paralysis with hypokalemia, T3 and T4 were higher than normal, TSH were lower than normal, paralysis of limb after hyperthyroidism did not recurrence. Conclusions The clinical experience of male patients with symmetrical paralysis of the limbs, should think of the possibility of hyperthyroidism and routine thyroid function tests.