The family of flaviviruses is one of the most medically important groups of emerging arthropod-borne viruses.Host cell cytoskeletons have been reported to have close contact with flaviviruses during virus entry,intracellular transport,replication,and egress process,although many detailed mechanisms are still unclear.This article provides a brief overview of the function of the most prominent flaviviruses-induced or-hijacked cytoskeletal structures including actin,microtubules and intermediate filaments,mainly focus on infection by dengue virus,Zika virus and West Nile virus.We suggest that virus interaction with host cytoskeleton to be an interesting area of future research.