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目的探讨无创正压通气(NIPPV)在治疗慢性阻塞性肺疾病(COPD)合并Ⅱ型呼吸衰竭的疗效。方法选择COPD合并Ⅱ型呼吸衰竭患者66例,根据治疗方法不同随机分为两组,观察组(33例)应用NIPPV加常规治疗;对照组(33例)仅用常规治疗。观察治疗前后两组呼吸频率、动脉血气分析结果、住院天数和病死率变化。结果观察组和对照组呼吸频率及动脉血气分析结果均有明显改善,观察组和对照组治疗比较有明显差异(P<0.05);观察组住院天数和死亡率明显低于对照组(P<0.05)。结论无创正压通气治疗COPD合并Ⅱ型呼吸衰竭可明显提高疗效,减少住院天数,降低死亡率。
Objective To investigate the efficacy of noninvasive positive pressure ventilation (NIPPV) in the treatment of chronic obstructive pulmonary disease (COPD) with type Ⅱ respiratory failure. Methods Sixty-six patients with COPD and type Ⅱ respiratory failure were randomly divided into two groups according to different treatment methods. The observation group (n = 33) was treated with NIPPV plus conventional therapy. The control group (n = 33) was treated with conventional therapy only. Before and after treatment, respiratory rate, arterial blood gas analysis results, days of hospitalization and mortality were observed. Results The respiratory rate and arterial blood gas analysis results of the observation group and the control group were significantly improved. There was significant difference between the observation group and the control group (P <0.05). The days of hospitalization and mortality in the observation group were significantly lower than those in the control group (P <0.05 ). Conclusion Noninvasive positive pressure ventilation in COPD with type Ⅱ respiratory failure can significantly improve the efficacy, reduce the number of days of hospitalization and reduce mortality.