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1897年Roux首先从牛的脓肿中观察到厌氧棒状杆菌(Corynebacterium ParvumC P),并在巴斯德研究所对厌氧棒状杆菌进行了研究。在较长的时间里,不只注意到对分离菌株的生物学性质和致病性等方面的研究,并发现该菌对网内系(RES)有激活作用和抑瘤作用,直至1967年才制成菌苗进行临床试用和免疫机理等方面的研究。目前已知厌氧棒状杆菌是一种非特异性淋巴网状内皮系统激活佐剂。能诱导淋巴网状内皮系统组织的高度增生,表现为巨噬细胞的吞噬活力、粘附力、溶酶体酶活性的增
In 1897 Roux first observed Corynebacterium parvum CP from bovine abscesses and Corynebacterium analefaciens was studied at the Pasteur Institute. Over a long period of time, not only the biological properties and pathogenicity of the isolated strains were noticed, but it was found that the bacteria had an activation and antitumor effect on the intra-reticular system (RES) until 1967 Into the vaccine for clinical trials and immune mechanisms and other aspects of research. It is known that Corynebacterium analefaciens is a non-specific lymphatic reticuloendothelial activation adjuvant. Can induce lymphatic reticuloendothelial system tissue hyperplasia, manifested as phagocytic activity of macrophages, adhesion, increased lysosomal enzyme activity