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阿司匹林(ASA)是一种环氧化酶抑制剂,其使用已有近百年历史。ASA属解热、镇痛类药物,具有解热、镇痛、抗风湿和抑制血小板聚集及抗凝作用。近年来广泛用于防止心脑血管病取得满意效果。本文参阅相关文献将阿司匹林的临床应用综述如下。1 ASA的作用机制王应立等分析其机制有以下几点:①延缓冠状动脉粥样硬化的进程。新近的研究资料提示,ASA具有抗氧化作用,血清丙二醛(MDA)是机体过氧化反应(CPR)的主要终产物,其水平高低反应了体内CPR的状态,发生CPR的直接作用是体内大量的自由基产生,其中毒性最大的是超氧阴离子(O_2~-)和羟自由基(OH),在动脉粥样硬化形成过程中MDA含量明显升高,提示
Aspirin (ASA) is a cyclooxygenase inhibitor that has been in use for almost a century. ASA is antipyretic, analgesic drugs, with antipyretic, analgesic, anti-rheumatic and inhibit platelet aggregation and anticoagulation. In recent years, widely used to prevent cardiovascular disease to obtain satisfactory results. This article refers to the relevant literature the clinical application of aspirin are summarized below. 1 The mechanism of action of ASA Wang Ying and other analysis of the mechanism of the following points: ① delay the process of coronary atherosclerosis. Recent data suggest that ASA has anti-oxidant effects. Serum malondialdehyde (MDA) is the major end product of the body’s peroxidation (CPR) and its level reflects the state of CPR in vivo. The direct effect of CPR occurs in vivo Of free radicals, the most toxic of which are superoxide anion (O 2 -) and hydroxyl radical (OH), the content of MDA in the process of atherosclerosis was significantly increased, suggesting