代谢组学(metabonomics/metabolomice)是近年来继蛋白质组学、基因组学、转录组学后又一迅速发展的学科。蛋白质组学和基因组学具有累加性和补偿性,其有效的微小变化可在代谢物上得到放大,故而代谢组学是研究的最终方向。通过研究机体的代谢组变化,能更简易、精确地反映机体状态。作为一门新兴学科,其已成为后基因组时代的研究热点。而骨肉瘤作为骨肿瘤中危害性巨大的疾病,能早期发现、早期预防、早期治疗是减少其危害的最有效办法。骨肉瘤的发生、发展是一个受多基因调 Metabolomics (metabonomics / metabolomice) in recent years following the proteomics, genomics, transcriptomics and rapid development of the discipline. Proteomics and genomics are additive and compensatory, and their effective small changes can be magnified on metabolites. Therefore, metabolomics is the final direction of the research. By studying the body’s metabolic group changes, can more easily and accurately reflect the state of the body. As a new discipline, it has become a research hotspot in the post-genomic era. Osteosarcoma as a huge risk in bone tumors, early detection, early prevention, early treatment is the most effective way to reduce its harm. The occurrence and development of osteosarcoma is a multi-gene mediated