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目的:探究细胞学、HPV高危型检测在宫颈病变筛查中的应用价值。方法:择取东莞市东城人民医院2011年6月至2015年6月收治的进行宫颈癌筛查检测的女性患者180例,对收治的所有患者均进行高危型HPV基因检测、宫颈液基薄层细胞检测与联合检测方案等,将病理检测结果作为确诊依据。结果:180例患者进行病理学诊断显示正常34例,宫颈上皮内瘤变(CIN)Ⅰ86例,CINⅡ34例,CINⅢ23例,浸润癌3例,其中不典型鳞状细胞、低度鳞状上皮内病变、高度鳞状上皮内病变、鳞状细胞癌HPV阳性率分别为52.14%、71.43%、90.00%、100.00%;HR-HPV检测敏感度为94.15%,特异度为73.30%,TCT检测敏感度为86.52%,特异度为90.33%,两种方法联合检测后的敏感度为97.20%,特异度为71.15%。结论:对宫颈病变采用HPV联合细胞学检测方案进行筛查的应用价值显著,利于对宫颈癌进行早期诊断,提高筛查有效率。
Objective: To explore the value of cytology and high-risk HPV testing in cervical lesions screening. Methods: A total of 180 female patients with cervical cancer screening were selected from Dongcheng People’s Hospital of Dongguan City from June 2011 to June 2015. All the patients were examined for high-risk HPV gene, Cell detection and joint detection programs, the pathological test results as the basis for diagnosis. Results: The pathological diagnosis of 180 patients showed normal 34 cases, cervical intraepithelial neoplasia (CIN) Ⅰ 86 cases, CIN Ⅱ 34 cases, CIN Ⅲ 23 cases, invasive carcinoma 3 cases, including atypical squamous cells, low grade squamous intraepithelial lesion , The positive rate of HPV in squamous cell carcinoma was 52.14%, 71.43%, 90.00% and 100.00% respectively. The detection sensitivity of HR-HPV was 94.15% and the specificity was 73.30%. The sensitivity of TCT was 86.52% and specificity of 90.33%. The sensitivity and specificity of the two methods were 97.20% and 71.15%, respectively. Conclusion: The value of screening HPV cervical cytology test for cervical lesions is significant, which is conducive to the early diagnosis of cervical cancer and improve the screening efficiency.