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目的:探讨左旋多巴联合卡比多巴治疗儿童难治性弱视的临床疗效。方法:对36例(63眼)4.5～14岁经遮盖治疗未愈、视力稳定6月无变化的患儿予以左旋多巴(1.5mg/kg)、卡比多巴(0.38mg/kg)口服,每日3次,连续3月,观察视力、融合功能、立体视觉及网膜光敏感度、注视暗点的变化及药物的副作用。结果:服药3月,63眼弱视眼中视力提高者占88.89％(平均提高2.27±1.26行),10例融合功能改善,6例恢复立体视觉。视网膜光敏感度明显改善,19眼注视暗点消失,6眼缩小。基本治愈率42.86％,且副作用小。结论:左旋多巴联合卡多巴能有效地提高难治性弱视患儿的视功能,且副作用少。眼科学报1998;14:238～241。
Objective: To investigate the clinical efficacy of levodopa combined with carbidopa in the treatment of refractory amblyopia in children. Methods: Totally 36 children (63 eyes) aged 4.5 to 14 years were treated with levodopa (1.5mg / kg) and carbidopa (0.38mg / kg) orally after treatment without masking and stable visual acuity in June. , 3 times a day for 3 consecutive months, observed visual acuity, fusion function, stereoscopic vision and retinal light sensitivity, watching dark spots and drug side effects. Results: In March, the visual acuity in 63 eyes of amblyopic eyes accounted for 88.89% (average increase of 2.27 ± 1.26 lines), the fusion function of 10 cases was improved, and the stereoscopic vision was restored in 6 cases. Retinal light sensitivity was significantly improved, 19 eyes dark spots disappeared, 6 eyes narrowed. The basic cure rate of 42.86%, and side effects. Conclusion: L-dopa combined with cardiopulmonary can effectively improve the visual function of children with refractory amblyopia, and less side effects. Journal of Ophthalmology 1998; 14: 238 ~ 241.