论文部分内容阅读
目的调查舟山群岛地区妇女高危型人乳头状瘤病毒(high risk human papilloma virus,HR-HPV)感染现状及其与宫颈病变的关系。方法 2008年7月至2011年10月,采用第二代杂交捕获(HC-Ⅱ)检测技术对5412例妇女进行HR-HPV病毒负荷量检测,对HR-HPV阳性感染者行阴道镜下宫颈活组织细胞病理学分析。结合人口学及流行病学资料进行危险因素分析。结果舟山地区妇女HR-HPV阳性感染率为20.01%(1083/5412),并随年龄增长呈下降趋势(P<0.01)。农村人群阳性率高于城市人群,娱乐场所从业人员高于其他职业人群,暂住人群高于常住人群,只受过高中及以下教育人群高于受过大专及以上教育人群,差异均有统计学意义(P<0.01)。HR-HPVDNA阳性患者中,宫颈上皮内瘤样变(cervical Intraepithelial neoplasias,CINⅠ)、CINⅡ、CINⅢ和宫颈癌的检出率分别为11.63%、9.88%、11.63%和3.69%,且检出率均随着病毒负荷量增加呈上升趋势(P<0.01)。结论舟山地区妇女HR-HPV感染阳性率及HR-HPV阳性者宫颈病变检出率均较高,有必要通过开展广泛的HR-HPV筛查和阳性者定期随访,及时发现宫颈病变。
Objective To investigate the status of women with high-risk human papilloma virus (HR-HPV) infection in Zhoushan Archipelago and its relationship with cervical lesions. Methods From July 2008 to October 2011, HR-HPV viral load was detected in 5412 women using HC-Ⅱ detection technology. Colposcopic cervical activity Histopathological analysis. Analysis of risk factors with demographic and epidemiological data. Results The positive rate of HR-HPV infection in Zhoushan was 20.01% (1083/5412), and decreased with age (P <0.01). The positive rate of rural population was higher than that of urban population, and the number of entertainment workers was higher than that of other occupational groups. The number of temporary residents was higher than that of resident population, and only higher than that of middle school and below educated people. The differences were statistically significant ( P <0.01). The detection rates of cervical intraepithelial neoplasias (CINⅠ), CINⅡ, CINⅢ and cervical cancer were 11.63%, 9.88%, 11.63% and 3.69% respectively in HR-HPVDNA positive patients With the increase of viral load, the trend of increase (P <0.01). Conclusion The positive rates of HR-HPV infection and HR-HPV positive cervical lesions in Zhoushan area are high. It is necessary to detect cervical lesions in time through extensive HR-HPV screening and regular follow-up.