Genetic interactions in translational research on cancer

来源 :世界医学遗传学杂志 | 被引量 : 0次 | 上传用户：zhuzihai

【摘要】

：

Genetic interactions are functional crosstalk among different genetic loci that lead to phenotypic changes,such as health or viability alterations.A disease or

【作者】

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Bingliang Fang

【机构】

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DepartmentofThoracicandCardiovascularSurgery

【出处】

：

世界医学遗传学杂志

【发表日期】

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2011年1期

【关键词】

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CANCER DRUG DISCOVERY MUTATION GENETIC interaction Target identification CHEMORE

【基金项目】

：

Supported by The National Institutes of Health through MD Anderson’s Cancer Center Support Grant CA016672,which supports the Lung Program,National Cancer Institute grants R01 CA092487 and R01 CA 12495

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Genetic interactions are functional crosstalk among different genetic loci that lead to phenotypic changes,such as health or viability alterations.A disease or lethal phenotype that results from the combined effects of gene mutations at different loci is

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