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目的:观察2型糖尿病患者应用黄连素治疗对血糖及周围神经病变的影响。方法:将110例2型糖尿病周围神经病变患者随机数字表法分为2组各55例,对照组采用甲钴胺进行治疗,观察组在对照组治疗基础上加用黄连素治疗。比较2组周围神经病变疗效,观察空腹血糖、糖化血红蛋白(Hb A1c)变化,检测感觉神经传导速度(SNCV)和运动神经传导速度(MNCV)。结果:治疗后观察组空腹血糖、Hb A1c较治疗前均降低(P<0.05);观察组空腹血糖、Hb A1c低于对照组(P<0.05)。总有效率2组比较,差异无显著性意义(P>0.05)。治疗后观察组和对照组正中神经和腓神经的SNCV、MNCV较治疗前均显著延长且差异均具有显著性意义(P<0.05);观察组治疗后正中神经和腓神经的SNCV、MNCV较对照组延长更加显著(P<0.05)。结论:2型糖尿病患者应用甲钴胺与黄连素联合治疗能显著提高治疗效果。
Objective: To observe the effect of berberine on blood glucose and peripheral neuropathy in type 2 diabetic patients. Methods: A total of 110 patients with type 2 diabetic peripheral neuropathy were randomly divided into 2 groups of 55 patients. The control group was treated with methylcobalamin. The observation group was treated with berberine on the basis of the control group. The curative effect of peripheral neuropathy was compared between the two groups. Changes of fasting blood glucose, HbA1c, sensory nerve conduction velocity (SNCV) and motor nerve conduction velocity (MNCV) were measured. Results: After treatment, fasting blood glucose and Hb A1c in observation group were lower than those before treatment (P <0.05). Fasting blood glucose and Hb A1c in observation group were lower than those in control group (P <0.05). The total effective rate of two groups, the difference was not significant (P> 0.05). After treatment, the SNCV and MNCV of the median nerve and the peroneal nerve in the observation group and the control group were significantly longer than those before treatment (P <0.05). The SNCV and MNCV of the median nerve and peroneal nerve in the observation group were significantly higher than those in the control group Group extension was more significant (P <0.05). Conclusion: The combination of mecobalamin and berberine can significantly improve the therapeutic effect in type 2 diabetic patients.