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In this study, a scintillation detector was devel-oped to measure the space proton effective dose for astronauts based on the proton effective dose conversion coefficients provided by Inteational Commission on Radiological Protection Report No. 116. In the Monte Carlo N-Particle Transport Code X (version 2.6.0) simu-lation process, by modulating the depth and solid angle of truncated conical holes in an iron shell from lower-energy protons to higher-energy protons, the energy deposited in the scintillator by isotropic protons was nearly proportional to the corresponding effective dose, with a maximum rel-ative deviation of 13.28% at thirteen energy points in the energy range of 10-400 MeV. Therefore, the detector can monitor proton effective dose indirectly in real time by measuring the deposited energy. We calibrated the photo-electric conversion efficiency of the detector at the cobalt source, tested the response of the detector in the energy range of 30-100 MeV in unidirectional proton field, and validated the simulation with the experimental results.