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目的观察吸入用布地奈德混悬液治疗小儿哮喘的疗效及对患儿T淋巴细胞亚群的影响。方法选取2014年11月-2015年10月医院儿科收治哮喘患儿77例,随机分为对照组38例和观察组39例。对照组采用常规治疗,观察组在常规治疗基础上加用吸入用布地奈德混悬液进行治疗。观察2组患儿治疗前后呼吸、心率、T淋巴细胞亚群水平及治疗后哮喘恢复时间、临床疗效。结果治疗后2组患儿呼吸、心率均高于治疗前,差异有统计学意义(P<0.05);且治疗后观察组患儿的呼吸、心率低于对照组,差异有统计学意义(P<0.05)。治疗后2组患儿CD4+、CD4+/CD8+低于治疗前,差异有统计学意义(P<0.05);且治疗后观察组CD4+、CD4+/CD8+低于对照组,差异有统计学意义(P<0.05)。观察组总有效率高于对照组,差异有统计学意义(P<0.05)。结论吸入用布地奈德混悬液治疗小儿哮喘可降低患儿呼吸、心率,调节患儿T淋巴细胞亚群,提高临床疗效,值得临床应用。
Objective To observe the therapeutic effect of inhaled budesonide suspension on pediatric asthma and its effect on T lymphocyte subsets in children. Methods Totally 77 children with asthma admitted to our hospital from November 2014 to October 2015 were randomly divided into control group (n = 38) and observation group (n = 39). The control group was treated by routine treatment, and the observation group was treated with budesonide suspension for inhalation on the basis of routine treatment. The changes of respiration, heart rate, T lymphocyte subsets and asthma recovery time before and after treatment in two groups were observed, and the clinical curative effect was observed. Results After treatment, respiration and heart rate in both groups were significantly higher than those before treatment (P <0.05). After treatment, respiration and heart rate in the observation group were lower than those in the control group (P <0.05). After treatment, CD4 +, CD4 + / CD8 + in the two groups were lower than before treatment, the difference was statistically significant (P <0.05); after treatment, CD4 +, CD4 + / CD8 + in the observation group was lower than that in the control group 0.05). The total effective rate of observation group was higher than that of control group, the difference was statistically significant (P <0.05). Conclusion Inhalation of budesonide suspension in children with asthma can reduce respiratory rate, heart rate, regulate children’s T lymphocyte subsets and improve clinical efficacy, which is worthy of clinical application.