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在科特迪瓦阿比让市,HIV感染并发结核的患者与单纯肺结核患者的年死亡率分别为20.3％和2.2％。研究表明,前者的高死亡率主要由其它机会感染所致,最常见的是沙门菌感染、等孢子球虫病、脑弓形虫病及细菌性肺炎等。作者采用随机安慰剂对照研究评价了TMP-SMZ预防机会感染的效果。 以1995年10月～1998年4月登记在册的771例HIV-1阳性(或同时伴HIV-2阳性)并发肺结核的患者为研究对象,年龄中
In Abidjan, Côte d’Ivoire, the annual mortality rates among patients with HIV-infected tuberculosis and patients with tuberculosis were 20.3% and 2.2%, respectively. Studies have shown that the high mortality rate of the former is mainly caused by other opportunistic infections, the most common are Salmonella, Sporidioides, Toxoplasmosis and Bacterial Pneumonia. The authors evaluated the effect of TMP-SMZ in preventing opportunistic infections using a randomized placebo-controlled study. A total of 771 HIV-1-positive (or concurrent HIV-2-positive) patients with pulmonary tuberculosis who were enrolled from October 1995 to April 1998 were enrolled in this study.