细胞因子白细胞介素(IL)-17包括6个家族成员、5个受体及其配体,主要由Th17细胞分泌,具有免疫调节、粒细胞募集、介导信号转导等多种作用。Act1在IL-17介导的信号转导通路中起着关键作用,信号通路下游激活NF-κB,还可以协同激活JAK1、JAK2和三磷酸肌醇激酶,上调炎性基因表达,介导炎性疾病的发生。多发性硬化的发病机制复杂而未明,IL-17介导的信号转导通路与多发性硬化发病相关。 The cytokine interleukin (IL) -17 includes six family members, five receptors and their ligands, secreted mainly by Th17 cells and has multiple roles in immune regulation, recruitment of granulocytes, and mediation of signal transduction. Act1 plays a key role in the signal transduction pathway mediated by IL-17. Activation of NF-κB downstream of signaling pathway can also activate JAK1, JAK2 and inositol triphosphate kinase, up-regulate inflammatory gene expression and mediate inflammatory The occurrence of the disease. The pathogenesis of multiple sclerosis is complex and unknown, IL-17-mediated signal transduction pathway associated with multiple sclerosis.