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目的:探讨南沙参多糖(RAPs)对肝损伤的保护作用。方法:采用四氯化碳(CCl_4)诱导小鼠急性肝损伤模型,测定血清丙氨酸氨基转移酶(ALT)、天冬氨酸氨基转移酶(AST)活性、肝匀浆中超氧化物歧化酶(SOD)活性及丙二醛(MDA)含量,观察肝组织病理学改变。结果:RAPS各剂量组(2000,1000,500 mg·kg~(-1))不仅能显著降低肝损伤小鼠血清AST、ALT活性,而且能够降低肝损伤小鼠肝组织MDA含量,并能提高SOD活性;病理形态学观察显示,RAPS能够明显减轻肝细胞肿胀、减少中性粒细胞浸润,其对急性肝损伤具有治疗作用。结论:RAPS对CCl_4诱导的急性肝损伤具有显著的保护作用,该保护作用可能与其抗氧化作用有关。
Objective: To investigate the protective effects of polysaccharides from Nanxa ginseng (RAPs) on liver injury. METHODS: Acute hepatic injury model in mice was induced with carbon tetrachloride (CCl_4). Serum alanine aminotransferase (ALT), aspartate aminotransferase (AST) activity, superoxide dismutase in liver homogenate were measured. (SOD) activity and malondialdehyde (MDA) content were observed in histopathological changes of the liver. RESULTS: RAPS doses (2000, 1000, 500 mg·kg -1) not only significantly reduced the serum AST and ALT activity in mice with liver injury, but also decreased the MDA content in liver tissues of mice with liver injury and increased the MDA content. SOD activity; pathological observations showed that RAPS can significantly reduce liver cell swelling and neutrophil infiltration, which has a therapeutic effect on acute liver injury. Conclusion: RAPS has a significant protective effect on acute liver injury induced by CCl_4. The protective effect may be related to its anti-oxidation effect.