论文部分内容阅读
目的:探讨n 99Tcn m-亚甲基二膦酸盐(MDP)SPECT/CT显像在儿童朗格汉斯细胞组织细胞增生症(LCH)中的临床价值。n 方法:回顾性分析2018年6月至2019年10月期间经武汉儿童医院病理及免疫组织化学确诊为LCH的13例患儿[男8例，女5例，年龄：1～11(4.2±2.8)岁]的n 99Tcn m-MDP骨显像及SPECT/CT显像的特点，评估骨骼病灶的部位、数目、影像特征及最大标准摄取值(SUVn max)等。n 结果:在13例患儿中共发现18个骨骼病灶(8个位于椎体，3个位于股骨，3个位于颅骨，2个位于肋骨，1个位于肩胛骨，1个位于坐耻骨)；9例患儿骨病变为单发，4例为多发。18个病灶中，有17个在CT图像上均表现为不同程度的溶骨性骨质破坏，15个可见软组织密度肿块，3个可见边缘硬化表现，所有病灶在SPECT图像上均为不同程度的显像剂摄取增高[病灶SUVn max为1.22～15.57(8.67±3.19)]。n 结论:99Tcn m-MDP SPECT/CT显像具有功能与形态影像相结合的优势，在儿童LCH的早期诊断、分型及疗效评价中具有一定的临床应用价值，可为临床提供客观依据。n “,”Objective:To explore the clinical value of n 99Tcn m-methylene diphosphonate (MDP) SPECT/CT imaging in Langerhans cell histiocytosis (LCH) in children.n Methods:From June 2018 to October 2019, the imaging characteristics of n 99Tcn m-MDP SPECT/CT imaging in 13 children (8 males, 5 females; age: 1-11 (4.2±2.8) years) with LCH confirmed by pathology and immunohistochemistry in Wuhan Children′s Hospital were analyzed retrospectively. The location, number, imaging manifestations, and maximum standardized uptake value (SUVn max) of the lesions were evaluated.n Results:There were 18 lesions (8 in the vertebral body, 3 in the femur, 3 in the skull, 2 in the rib, 1 in the shoulder blade, 1 in the sciatic and pubic bone) in 13 children, including 9 with single lesion and 4 with multiple lesions. Of 18 lesions, 17 showed different degrees of osteolytic bone destruction, 15 presented as soft tissue masses, and 3 showed marginal sclerosis on CT imaging. All lesions showed increased n 99Tcn m -MDP uptake (SUVn max: 1.22-15.57 (8.67±3.19)).n Conclusion:99Tcn m-MDP SPECT/CT has the advantage of combining functional and morphological imaging, and is helpful in the early diagnosis, clinical classification and evaluation of curative effect of children′s LCH, which provides objective basis for clinical practice.n