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目的:评价血清中甲状腺特异性抗体的存在对乳腺癌患病风险的影响,为评估乳腺癌的预后及制定治疗方案提供理论依据。方法:计算机检索Medline(1950~2012)、EMBASE(1949~2012)、Pubmed(1946~2012)、Current Contents Connect(1998~2012)和Google Scholar(1992~2012)等英文数据库。收集关于甲状腺特异性抗体与乳腺癌(Breast Cancer,BC)相关性分析的横断面研究或队列研究。按Cochrane系统评价方法,评价所纳入研究的文献质量,有效数据采用RevMan5.2软件进行系统评价。结果:最终纳入6项研究,共计6945例患者。系统评价结果显示:乳腺癌的风险会随血清中甲状腺特异性抗体(包括甲状腺过氧化物酶抗体anti-TPO和甲状腺球蛋白抗体anti-TG)的存在而增加(anti-TPO OR 2.51,95%CI:1.94-3.25;anti-TG 2.67,95%CI:1.65-4.33)。结论:乳腺癌的风险会随血清中甲状腺特异性抗体的存在而增加,甲状腺特异性抗体可能为乳腺癌预后的评估以及治疗原则的制定提供理论基础。
Objective: To evaluate the influence of thyroid-specific antibody in serum on the risk of breast cancer, and to provide a theoretical basis for assessing the prognosis of breast cancer and formulating the treatment plan. Methods: The English databases such as Medline (1950 ~ 2012), EMBASE (1949 ~ 2012), Pubmed (1946 ~ 2012), Current Contents Connect (1998 ~ 2012) and Google Scholar (1992 ~ 2012) were searched. Cross-sectional studies or cohort studies were collected on the correlation analysis of thyroid-specific antibodies with breast cancer (Breast Cancer, BC). According to the Cochrane systematic review method, the quality of the literature included in the study was evaluated, and valid data was systematically evaluated using RevMan5.2 software. Results: Six studies were finally included for a total of 6,945 patients. The results of a systematic review showed that the risk of breast cancer increased with the presence of thyroid-specific antibodies in serum (including anti-TPO and anti-TG) (anti-TPO OR 2.51, 95% CI: 1.94-3.25; anti-TG 2.67, 95% CI: 1.65-4.33). CONCLUSIONS: The risk of breast cancer increases with the presence of thyroid-specific antibodies in serum. Thyroid-specific antibodies may provide a theoretical basis for the assessment of prognosis and the development of therapeutic principles.