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用大骨节病病区陕西永寿县产的玉米、小麦等按病区生活条件配制的饲料喂养大白鼠幼仔的动态研究表明:喂养1～2个月后出现了红细胞膜脂组成的改变,红细胞的硒水平、GSH-Px 活性分别在喂养2及3个月后明显降低,脂质过氧化产物明显增高,软骨脂质也出现了类似的改变;并略迟于红细胞。血浆中的 GOT、CK、LDH 等酶活性依次在第3、4、5个月达到明显高于对照的水平,而 GPT 几乎不变。与大骨节病患者的酶谱变化基本一致。亦可见代表结缔组织、肌肉损害的尿羟脯氨酸、肌酐量降低等大骨节病时的改变。上述各项改变的有序性及其制约关系的阐明在探讨病因、发病机理及早期诊断的科学依据上均有重要意义。
Kashin-Beck disease in Shaanxi Province, Yongshou County, corn, wheat and other ward formulated by the living conditions of feed-fed mice pups dynamic study showed that: 1 to 2 months after feeding the red blood cell membrane lipid composition changes, red blood cells Selenium levels, GSH-Px activity were significantly reduced after 2 and 3 months of feeding, lipid peroxidation products were significantly increased cartilage lipid also appeared similar changes; and slightly later than the red blood cells. Plasma GOT, CK, LDH and other enzyme activities were significantly higher than the control in the first 3,4,4 months, while the GPT almost unchanged. The changes of Zymogram in Kashin-Beck disease patients were basically the same. Can also be seen on behalf of connective tissue, muscle damage of hydroxyproline, creatinine and other changes in Kashin-Beck disease. The orderliness of the above changes and the clarification of the relationship between them are of great significance in exploring the etiology, pathogenesis and scientific basis of early diagnosis.