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目的:确定抑郁焦虑情绪对CA复发和细胞免疫的影响。方法:采用抑郁自评量表(SDS)和焦虑自评量表(SAS)对100例初诊CA进行问卷调查,评估其情绪状态。SDS>50和/或SAS>50为抑郁焦虑者,其余患者为非抑郁焦虑者。选择健康体检32人为对照。流式细胞技术测定外周血Treg细胞水平。随后观察两组CA治疗后的复发率。结果:CA组外周血Treg细胞水平为(8.03±2.14)%,显著高于正常对照组(5.28±1.21)%(P<0.05);抑郁焦虑组外周血Treg细胞水平为(8.64±2.12)%,显著高于无抑郁焦虑组(7.55±2.05)%(P<0.05)。治疗后抑郁焦虑组第1、2、3、6个月的复发率均高于无抑郁焦虑组。结论:抑郁和/或焦虑情绪可加剧CA患者细胞免疫功能的抑制,导致CA更易复发。
Objective: To determine the effect of depression and anxiety on CA recurrence and cellular immunity. Methods: A total of 100 newly diagnosed CA patients were surveyed by SDS and SAS to evaluate their emotional status. SDS> 50 and / or SAS> 50 are depressive anxiety and the rest are non-depressive anxiety. Select the health examination of 32 people as a control. Flow cytometry was used to determine the level of Treg cells in peripheral blood. Follow-up was observed after two groups of CA recurrence rate. Results: The level of Treg cells in the peripheral blood of CA group was (8.03 ± 2.14)%, significantly higher than that of the control group (5.28 ± 1.21)% (P <0.05) (7.55 ± 2.05)%, respectively (P <0.05). The recurrence rates in the first, second, third and sixth month of depression and anxiety group were higher than those without depression and anxiety group. Conclusions: Depression and / or anxiety may exacerbate the inhibition of cellular immune function in patients with CA, leading to a relapse of CA more easily.