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应用光镜及电镜观察了服用复方炔雌醚长效避孕药9～13年11例妇女的子宫内膜和13例服药2～11年后停药1～24个月妇女的子宫内膜。11例服药对象的子宫内膜对药物的反应良好,基本上是同步的。其中一例出现轻度腺囊性增生过长。服药者的子宫内膜腺上皮与正常内膜比较,细胞结构未见明显损害,主要差别是:(1)腺细胞的内质网扩大明显;(2)胞质中的退变结构及溶酶体增多,退变性暗细胞也增多;(3)核仁管道系统消失。药物引起的子宫内膜腺细胞超微结构的变化,停药后3～4个月即恢复正常。结果表明,长期服用低剂量的复方炔雌醚,子宫内膜组织未发生明显损害。
The endometrium of 11 women who took compound acetylene and diethylstilbestrol long-term contraceptives from 9 to 13 years and 13 women who took medicine from 1 to 24 months after taking medicine for 2 to 11 years were observed by light microscope and electron microscope. The endometrium in 11 patients who took the medication responded well to the drug and was essentially in synchronicity. One case of mild glandular cystic hyperplasia. The main difference between the endometrial glandular epithelium and the normal endometrium of the drug-eluting patients was that no significant damage was observed in the cell structure. The main differences were: (1) the endoplasmic reticulum of the glandular cells was obviously enlarged; (2) the degenerative structure in the cytoplasm and the lysosome Increased, degenerative dark cells also increased; (3) nucleolus duct system disappeared. Drug-induced changes in the ultrastructure of endometrial gland cells, 3 to 4 months after stopping to return to normal. The results show that long-term use of low doses of compound ethinyl estrone, endometrial tissue did not occur significant damage.