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蛇毒中存在着能直接溶解纤维蛋白的酶类。对这类酶的深入研究,不仅有助于阐明蛇伤中毒的病理机制,而且为其应用开发提供了理论基础。自1976年Ouyang和Huang首次从尖吻蝮蛇毒中获得纯化的纤维蛋白溶解酶(以下简称纤溶酶)以来,迄今已从不同科属的至少15种蛇毒中获得了25种以上的纯化纤溶酶,并对其分子结构、酶学特性及其出血活性的关系进行了深入地研究。现就这些方面的研究进展作一简要综述。
Snake venoms exist in the direct dissolution of fibrin enzymes. In-depth study of these enzymes not only help to clarify the pathological mechanism of snakebite poisoning, but also provide a theoretical basis for its application and development. Since 1976, Ouyang and Huang first obtained purified fibrinolytic enzyme (hereinafter referred to as plasmin) from Agkistrodon acutus, so far, more than 25 kinds of purified fibrinolysis have been obtained from at least 15 kinds of snake venom from different genera Enzyme, and its molecular structure, enzymatic properties and the relationship between hemorrhagic activity conducted in-depth study. Now a brief overview of the research progress in these areas.