论文部分内容阅读
[目的]通过观察三七总甙(PNS)对糖尿病肾病大鼠血栓素B2(TXB2)、6酮前列腺素F1α(6keto PGF1α)的影响,探讨PNS防治糖尿病肾病的作用及机制。[方法]采用高脂饲料喂养加尾静脉注射链脲佐菌素(STZ),建立2型糖尿病肾病大鼠模型,PNS低、高剂量组分别予PNS100、200mg/(kg·d)灌胃,12周后,测定空腹血糖(FBG)、血脂、24h尿微量清蛋白、TXB2、TXB2/6keto PGF1α。[结果]糖尿病组大鼠FBG、24h尿微量清蛋白、TXB2、TXB2/6keto PGF1α明显升高,PNS组以上各项指标均明显降低。[结论]PNS能有效防治糖尿病肾病的作用可能与降低TXB2、TXB2/6keto PGF1α有关。
[Objective] To observe the effect of Panax notoginseng scrofula (PNS) on thromboxane B2 (TXB2) and 6 keto prostaglandin F1α (6keto PGF1α) in diabetic nephropathy rats, and to explore the effect and mechanism of PNS on diabetic nephropathy. [Methods] High-fat diet and tail vein injection of streptozotocin (STZ) were used to establish a rat model of type 2 diabetic nephropathy. PNS low and high dose groups were given intragastrically with PNS 100 and 200 mg/(kg·d) respectively. After 12 weeks, fasting blood glucose (FBG), blood lipids, 24-h urine microalbumin, TXB2, and TXB2/6 keto PGF1α were measured. [Results] The levels of FBG, 24h urinary microalbumin, TXB2, TXB2/6keto PGF1α in diabetic rats were significantly higher than those in PNS group. [Conclusion] The effect of PNS on preventing and treating diabetic nephropathy may be related to the decrease of TXB2, TXB2/6keto PGF1α.