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自从七十年代初期,Krugman等人提出用自动免疫的方法预防乙型肝炎病毒(HBV)感染以来,各国学者都曾致力于血源性乙肝疫苗的研究,美法荷兰等国分别采用不同的制备方法,相继研制出了几种血源性乙肝疫苗,并采用不同的接种方案在各种人群中进行了大规模的现场观察性研究。结果表明血源性乙肝疫苗具有高度的免疫原性和预防HBV感染的作用。
Since the early 1970s, when Krugman et al. Proposed autoimmunity to prevent hepatitis B virus infection, scholars all over the world have devoted themselves to the study of blood-borne hepatitis B vaccine. Different countries, such as the United States and France, used different preparations Methods, have developed several blood-borne hepatitis B vaccine, and using different vaccination programs in a variety of people conducted a large-scale field observational studies. The results show that the blood-borne hepatitis B vaccine has a high degree of immunogenicity and the role of preventing HBV infection.