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目的:通过外周血淋巴细胞亚群在人类同种异体肾移植受者术后感染的动态变化,探讨其与感染类型及愈后的关系。方法:采用流式细胞仪,测定16例肾移植受者术后并发感染时外周血中CD3+、CD4+、CD8+细胞,并根据CD4+细胞计数及CD4+/CD8+比值,分析其与感染类型和愈后的关系。结果:(1)机会感染者外周血CD4+细胞计数明显低于普通感染组和术前(P<0.05),CD4+/CD8+比值亦显著降低(P<0.05)。而普通感染者CD4+细胞计数和CD4+/CD8+比例多在正常范围,且与术前相比较,差异不显著(P>0.05)。(2)CD4+细胞计数和(或)CD4+/CD8+比值明显降低者,往往预后较差。结论:根据外周血淋巴细胞亚群的动态变化,特别是CD4+细胞计数及CD4+/CD8+比值,可以初步判断肾移植受者感染类型及预后,并可指导临床合理用药。
OBJECTIVE: To investigate the dynamic changes of postoperative infection of peripheral blood lymphocyte subsets in human allogeneic kidney transplant recipients and to explore its relationship with infection type and prognosis. Methods: Flow cytometry was used to detect CD3 +, CD4 +, and CD8 + cells in peripheral blood of 16 renal transplant recipients with postoperative infection. According to the ratio of CD4 + cell count and CD4 + / CD8 + relationship. Results: (1) The CD4 + cell count in peripheral blood of patients with opportunistic infections was significantly lower than that of the common infection group and preoperatively (P <0.05), and the ratio of CD4 + / CD8 + was significantly lower (P <0.05). The CD4 + cell count and CD4 + / CD8 + ratio in the common infection were mostly in the normal range, with no significant difference (P> 0.05). (2) Patients with significantly lower CD4 + cell count and / or CD4 + / CD8 + ratio often have poor prognosis. Conclusion: According to the dynamic changes of peripheral blood lymphocyte subsets, especially the CD4 + cell count and the ratio of CD4 + / CD8 +, the type and prognosis of renal allograft recipients can be preliminarily determined and can guide clinical rational drug use.