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目的:了解云南省育龄人群红细胞叶酸水平,建立云南地区的红细胞叶酸参考范围。方法:对2013年1、4、7、10月在云南省第一人民医院遗传诊断中心门诊进行孕前咨询的普通育龄人群2 639例分别测定男女性不同年龄阶段红细胞叶酸浓度,建立本地区的红细胞叶酸参考范围,并比较不同性别、不同地区、不同民族之间的差异。结果:云南地区普通育龄人群20~29岁女性红细胞叶酸参考水平为11.31~35.73 ng/ml,20~29岁男性为10.85~33.59 ng/ml,女性叶酸测定数值较男性为高;在云南省各个民族之间叶酸水平差异无统计学意义(P>0.05)。结论:建立云南地区红细胞叶酸参考范围为云南地区育龄人群补充叶酸提供了理论依据。
Objective: To understand the level of erythrocyte folate in the reproductive-age population in Yunnan Province and to establish the reference range of erythrocyte folic acid in Yunnan Province. Methods: Totally 2639 children of ordinary reproductive age who were counseled before pregnancy in the diagnosis center of Yunnan First People’s Hospital in January, April, July and October 2013 were used to determine the concentrations of erythrocytes in different ages of men and women respectively, and to establish red blood cells Folic acid reference range, and compare different genders, different regions, different ethnic differences. Results: The folic acid reference level of erythrocytes in general fertility population of 20-29 years old in Yunnan was 11.31-35.73 ng / ml, while that of men aged 20-29 was 10.85-33.59 ng / ml. The folic acid test was higher in women than in men in Yunnan Province. There was no significant difference in the level of folate between ethnic groups (P> 0.05). Conclusion: The establishment of reference range of erythrocyte folic acid in Yunnan provides a theoretical basis for the supplementation of folic acid in the population of childbearing age in Yunnan.