论文部分内容阅读
帕金森病(Parkinson disease,PD)是一种中脑黑质致密部和纹状体多巴胺能神经元选择性减少的神经退行性疾病,目前有6个致病基因被证实可以引起遗传型单基因PD。mi R-7、mi R-153、mi R-205、mi R-34b/mi R-34c、mi R-494可以直接调控PD致病基因PARK1/PARK4、PARK2、PARK7和PARK8,mi R-34a、mi R-132、mi R-133b、mi R-320、mi R-433等可以调控多种与PD发病机制相关的基因,如与多巴胺能神经元发育有关的基因、与突触形成有关的基因、和与神经营养因子有关的基因等等。直接调控PD致病基因的mi RNA可能具有直接的治疗作用,而调节PD相关基因的mi RNA可能具有辅助治疗作用。mi RNA能够调控PD致病基因与相关基因的表达,是一种非常具有前景的治疗手段,为治疗PD提供了新思路。
Parkinson’s disease (PD) is a neurodegenerative disease with selective reduction of substantia nigra pars compacta and striatal dopaminergic neurons. At present, six pathogenic genes have been identified to cause genetic single gene PD. mi R-7, mi R-153, mi R-205, mi R-34b / mi R-34c and mi R-494 can directly regulate the expression of PD1 / PARK4, PARK2, PARK7 and PARK8, , Mi R-132, mi R-133b, mi R-320, mi R-433 can regulate a variety of genes related to the pathogenesis of PD, such as genes related to the development of dopaminergic neurons, which are involved in synapse formation Genes, and neurotrophic factor-related genes and so on. The miRNAs that directly regulate PD pathogenic genes may have a direct therapeutic effect, while the miRNAs that regulate PD-related genes may have adjuvant therapeutic effects. mi RNA can regulate the expression of PD causative genes and related genes, which is a very promising treatment and provides a new idea for the treatment of PD.