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目的:探讨分析新生儿高胆红素血症发生的原因以及与围产因素的关系。方法:对561例住院5～7天以上的新生儿(517例母乳喂养者占92.16%),与无任何原因的对照组561例每日用微量法测定新生儿血清胆红素(SB)浓度。针对黄疸出现的时间及SB比值进行对照比较。结果:561例有13种围产因素中胎龄、日龄、体重、喂养方式、性别、缩宫素的使用等6种因素经过检验差异有统计学意义(P<0.05或P<0.01)。子痫前期、胎膜早破、ABO血型不合等7种因素差异无统计学意义(P>0.05)。结论:对母乳喂养、低体重儿、应用缩宫素计划分娩等,高胆红素血症的发生率明显高于对照组,所以在临床上减少和预防母亲的各种围产因素,做好围产期保健工作,是预防新生儿高胆红素血症的有效措施。每日监测新生儿SB浓度也是观察和防治高胆红素血症发生的必要手段。
Objective: To explore the causes of neonatal hyperbilirubinemia and its relationship with perinatal factors. Methods: 561 newborns (517 breastfeeding cases accounted for 92.16%) who were hospitalized for 5 ~ 7 days were enrolled in this study. 561 newborns with no reason were measured daily for the concentration of serum bilirubin (SB) . Jaundice appeared for the time and SB ratio comparison. Results: There were 13 kinds of perinatal factors in 561 cases of gestational age, age, weight, feeding patterns, sex, the use of oxytocin and other six factors were tested statistically significant difference (P <0.05 or P <0.01). Preeclampsia, premature rupture of membranes, ABO incompatibility among the seven factors were not statistically significant (P> 0.05). Conclusion: The incidence of hyperbilirubinemia in breastfeeding, low birth weight children and planned delivery of oxytocin is significantly higher than that of the control group, so it can reduce and prevent various perinatal factors of the mother clinically Perinatal care work, is an effective measure to prevent neonatal hyperbilirubinemia. Daily monitoring of neonatal SB concentration is also necessary to observe and prevent hyperbilirubinemia.