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目的观察大剂量呋塞米静脉滴注治疗难治性充血性心力衰竭(CHF)的疗效。方法常规治疗效果差的CHF患者28例,应用大剂量呋塞米静脉滴注3～5d,观察利尿效应,监测治疗前、后血压、电解质、肌酐及血脂,治疗过程中适当补钠、钾和维持血压。结果27例病人尿量较治疗前明显增加(P<0.01)。心衰的临床症状和体征明显改善,仅1例因肾功能衰竭死亡。治疗后血压显著下降(P<0.05)。治疗前后电解质、血脂、肌酐无明显改变。结论在常规治疗下,加用静脉滴注大剂量呋塞米治疗难治性CHF是一种安全、有效的方法。
Objective To observe the effect of high-dose furosemide intravenous infusion on refractory congestive heart failure (CHF). Methods Twenty-eight CHF patients with poor conventional treatment were treated with intravenous infusion of high-dose furosemide for 3 to 5 days. The diuretic effect was observed. Blood pressure, electrolytes, creatinine and blood lipids were monitored before and after treatment. Sodium, potassium and Maintain blood pressure. Results The urine volume of 27 patients was significantly higher than that before treatment (P <0.01). Clinical symptoms and signs of heart failure improved significantly, only 1 patient died of renal failure. After treatment, blood pressure decreased significantly (P <0.05). Electrolytes, blood lipids, creatinine did not change significantly before and after treatment. Conclusions Under routine treatment, high-dose intravenous infusion of furosemide in the treatment of refractory CHF is a safe and effective method.