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目的 观察A型肉毒毒素治疗偏侧面肌痉挛、眼睑痉挛及Meige综合征的疗效。方法 对 40例偏侧面肌痉挛、9例眼睑痉挛、1例Meige综合征进行面部肌肉局部多点注射A型肉毒毒素 ,评价其治疗效果。结果 40例偏侧面肌痉挛者 ,完全缓解 1 5例 (38% ) ,明显缓解2 4例 (60 % ) ,1例无效 ;9例眼睑痉挛者 ,4例完全缓解 ,4例明显缓解 ,1例无效 ;1例Meige综合征部分缓解 ,总有效率达 96 %。起效时间平均 3天 ,缓解时间平均 3 5个月。局部副反应轻微、短暂 ,无全身反应及过敏反应。结论 A型肉毒毒素局部肌肉注射是治疗局限性肌肉痉挛的一种安全、有效的治疗方法。
Objective To observe the efficacy of botulinum toxin type A in the treatment of hemifacial spasm, blepharospasm and Meige syndrome. Methods 40 cases of hemifacial spasm, 9 cases of blepharospasm and 1 case of Meige syndrome were injected with botulinum toxin type A into facial muscles. The therapeutic effect was evaluated. Results Forty cases of hemifacial spasm were completely relieved in 15 cases (38%), 24 cases (60%) were completely relieved, and 1 case was ineffective. Nine cases of blepharospasm were completely relieved in 4 cases and relieved in 4 cases Cases were ineffective; 1 case of partial remission of Meige syndrome, the total effective rate of 96%. The mean onset time was 3 days and the average relief time was 35 months. Local minor side effects, transient, no systemic reactions and allergic reactions. Conclusion Botulinum toxin type A intramuscular injection is a safe and effective treatment for limited muscle spasms.