目的 :研究用复合人工骨治疗股骨头坏死的效果。材料与方法 :建立双侧股骨头内骨缺损模型 ,并分为 4组 :①bBMP/胶原 /珊瑚复合人工骨组 (95侧 )、②肌骨瓣组 (5侧 )、③单纯珊瑚组 (4侧 )、④对照组 (14侧 (为以上各组的对侧)。对造模后及植入后定时行普通X线、核素骨显像、MRI及CT检查。结果 :(1)核素骨显像示 :6周及 12周 ,I组股骨头核素摄取量静态相头 /干比升高 ,但血液相及血池相不升高。 (2 )MRI示 :10周 ,I组原骨缺损区内T1WI及T2 WI均为低信号区 ,提示多量新生骨形成 ,Ⅳ组T1WI及T2 WI示中部为高信号区 ,周围为环形低信号带 ,提示囊腔中为脂肪性骨髓 ,周围为硬化带。 (3)拍片及CT示 :14～ 16周 ,I组骨缺损大多完全闭合 ,珊瑚已吸收 ,其余各组骨缺损部分残留 ,Ⅳ组骨缺损囊壁硬化带形成。结论 :该复合人工骨有较强的传导成骨及诱导成骨作用 ,是修复股骨头骨缺损的良好移植材料 ,但它不能改善缺血坏死股骨头的血供 Objective: To study the effect of composite artificial bone in treating femoral head necrosis. MATERIALS AND METHODS: A bilateral femoral head bone defect model was established and divided into four groups: ①bBMP / collagen / coral artificial bone group (95 sides), ② muscular flap group (5 sides), ③ coral reef group (4) Side), ④ control group (14 sides, the contralateral side of the above groups) .By routine X-ray, radionuclide imaging, MRI and CT examination after modeling and at the time of implantation.Results: (1) Osteoblasts showed: the static head / head ratio of femoral head nuclide increased in group I at 6 weeks and 12 weeks, but the blood phase and blood pool did not increase. (2) MRI showed: 10 weeks, I T1WI and T2WI in the group of primary bone defect were low signal area, suggesting that a large number of new bone formation, Ⅳ group T1WI and T2 WI showed the middle of the high signal area, around the ring low signal band, suggesting that the cystic cavity of fatty bone marrow , Around the hardened zone. (3) film and CT showed: 14 to 16 weeks, most of the group I complete closure of bone defects, coral has been absorbed, the rest of the group remaining part of the bone defect, Ⅳ group of bone defect wall formation. : The composite artificial bone has strong osteogenesis-inducing and osteogenic effects and is a good graft material for repairing femoral skull defect, but it can not improve ischemic necrosis of the femoral head Blood supply