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系统性红斑狼疮的发病原因还不很明确,多数人认为是一种免疫复合物疾病,也有人认为是多源性的,与病毒、遗传及环境因素有关。DNA 及 DNA 复合物对肾脏损害关系较大,有人在活动性狼疮性肾炎患者血清中发现抗 DNA 抗体明显增加,C_3补体值下降,少数患者血中还能找到游离的 DNA。当 SLE 以肾脏病损为初发表现时,常误诊为肾小球肾炎或肾病综合征,在治疗上每易延误。本文就21例狼疮性肾炎的临床表现,分析了 SLE 各器官的病损率及其与肾损害的关系,并对狼疮性肾炎的治疗问题及其与原发性肾炎的鉴别诊断进行探讨。
The cause of systemic lupus erythematosus is not yet clear, most people think it is an immune complex disease, some people think it is multi-source, and the virus, genetic and environmental factors. DNA and DNA complexes have a great impact on kidney damage. Some people in the active lupus nephritis serum anti-DNA antibody was significantly increased, C_3 complement decreased, a small number of patients can find free DNA in the blood. When SLE with renal lesions as the initial performance, often misdiagnosed as glomerulonephritis or nephrotic syndrome, in the treatment of every delay. In this paper, 21 cases of lupus nephritis clinical manifestations, the analysis of the various organs of SLE lesions and its relationship with renal damage, and the treatment of lupus nephritis and its differential diagnosis with primary nephritis are discussed.