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多数肺囊性纤维变(CF)患者发生下呼吸道绿脓杆菌感染时需要广谱抗生素治疗以控制感染并限制肺损害的进程,β-内酰胺类与氨基糖苷类的协同杀菌作用是常采用的最有效疗法。以前研究发现Cefsulodin的血清浓度可因合用妥布拉霉素而降低。本研究旨在观察氨基糖苷类浓度是否受到不同种类β-内酰胺类的影响。作者选择14例肺囊性纤维化的病人并发假单胞菌属感染时用乙基西索米星治疗并观察了其在体内的药代动力学特性。患者年龄为4-21岁(平均14.3岁)。这些病人接受乙基
In most patients with pulmonary cystic fibrosis (CF), a broad-spectrum antibiotic regimen is required for infection of the lower respiratory tract Pseudomonas aeruginosa to control the infection and limit the progression of lung damage. Synergistic bactericidal effects of β-lactams and aminoglycosides are commonly used The most effective therapy. Previous studies have found that serum concentrations of Cefsulodin may be reduced by the administration of tobramycin. This study aimed to observe whether aminoglycoside concentrations are affected by different classes of β-lactams. The authors selected 14 patients with pulmonary cystic fibrosis complicated by Pseudomonas infection with ethyl Sisomicin and observed its pharmacokinetics in vivo. Patients were 4-21 years old (mean 14.3 years). These patients receive ethyl