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目的 探讨血管内皮因子 (VEGF)与鼻咽癌发生、生长及转移的关系。方法 应用LSAB免疫组织化学技术检测 5 0例鼻咽鳞状上皮癌组织中VEGF的表达。结果 鼻咽鳞状上皮癌组织中VEGF的表达明显高于鼻咽慢性炎症组织组 (P <0 0 5 ) ,在鼻咽癌组织中 ,Ⅲ ,Ⅳ期患者明显高于Ⅰ ,Ⅱ期 ,而有颈部淋巴结转移组又明显高于无颈部淋巴结转移组 (P <0 0 5 )。结论 VEGF可作为判断鼻咽癌的发生、转移及预后的临床指标之一
Objective To investigate the relationship between vascular endothelial growth factor (VEGF) and the occurrence, growth and metastasis of nasopharyngeal carcinoma. Methods LSAB immunohistochemistry was used to detect the expression of VEGF in 50 cases of nasopharyngeal squamous cell carcinoma. Results The expression of VEGF in nasopharyngeal squamous cell carcinoma was significantly higher than that in chronic inflammation of nasopharyngeal tissues (P <0 05). In NPC tissues, the expression of VEGF was significantly higher in stage Ⅲ and Ⅳ than in stage Ⅰ and Ⅱ There was a significant increase in cervical lymph node metastasis compared with those without cervical lymph node metastasis (P <0.05). Conclusion VEGF can be used as one of the clinical indicators to judge the occurrence, metastasis and prognosis of nasopharyngeal carcinoma